Transplanted microvascular endothelial cells promote oligodendrocyte precursor cell survival in ischemic demyelinating lesions
نویسندگان
چکیده
منابع مشابه
Extracellular Vesicles from Vascular Endothelial Cells Promote Survival, Proliferation and Motility of Oligodendrocyte Precursor Cells
We previously examined the effect of brain microvascular endothelial cell (MVEC) transplantation on rat white matter infarction, and found that MVEC transplantation promoted remyelination of demyelinated axons in the infarct region and reduced apoptotic death of oligodendrocyte precursor cells (OPCs). We also found that the conditioned medium (CM) from cultured MVECs inhibited apoptosis of cult...
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We show that cerebral endothelial cells secrete trophic factors that support the survival and proliferation of rat oligodendrocyte precursor cells (OPCs). This OPC-supportive phenomenon was mediated by Akt and Src signaling pathways. Noncytotoxic levels of oxidative stress downregulate trophic factor production and disrupt the ability of cerebral endothelial cells to support OPCs. These data su...
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PURPOSE Glaucoma is a common neurodegenerative disease for which current therapies are often insufficient; thus, new neuroprotective strategies are an important goal. Stem cells are attracting increasing attention as mediators of neuroprotection, often conferred via the trophic support of injured neurons. The purpose of our investigation was to determine whether oligodendrocyte precursor cells ...
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Our interest in developmental timing began with a surprising experimental result obtained by Erika Abney, an immunologist who joined our group in the late 1970s. We had earlier defined a set of cell-type-specific markers that allowed us to distinguish the major types of glial cells found in suspensions and cultures of rat central nervous system (CNS) cells: astrocytes, which are heterogeneous a...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2015
ISSN: 0022-3042
DOI: 10.1111/jnc.13262